Russell K. Portenoy, MD Beth Israel Medical Center Every day, 36 million Americans take an over-the-counter (OTC) painkiller, usually acetaminophen (Tylenol), ibuprofen (Advil, Motrin) or aspirin. We take those medications to stop a headache… ease an arthritis flare-up… soothe a sore shoulder after a weekend of yard work… or relieve any one of the everyday… Continue reading Guide to Over-the-Counter Painkillers